An experimental mesothelioma drug that holds orphan drug status in the U.S. and Europe is being tested for the first time in Russia. Although NGR-hTNF, a vascular inhibitor developed by Italy-based MolMed S.p.A., has been tested in Europe for several years, the move into Russia is a first for the company.
MolMed announced the move into Russia in a press release, noting that the country is likely to experience a “higher medical need” for mesothelioma treatment in the next several decades. The U.S. Geological Survey says Russia produced and used more asbestos, the leading cause of mesothelioma, in the three decades leading up to 2003. Company CEO Claudio Bordignon called the move “an important step in the challenge against mesothelioma”.
NGR-hTNF is a has been tested against of range of cancers including colorectal cancer, small-cell lung cancer, and ovarian cancer and is designated as an orphan drug (a drug designed to treat rare diseases) for mesothelioma and liver cancer in the U.S. and Europe. High doses of the drug have also been shown to be effective for certain kinds of tumors in the arms and legs. MolMed plans to recruit 100 patients in Russia and Europe for the Phase II trial of the drug as a first-line treatment for mesothelioma.
At the same time, NGR-hTNF is being tested in a Phase III trial as a long-term maintenance therapy for patients whose mesothelioma has returned after first-line treatment. The drug is well-tolerated by most patients, potentially making it a good choice for long-term treatment.
Malignant pleural mesothelioma (MPM) is a type of soft tissue sarcoma, a cancer that develops in the tissues that connect, support or surround other organs in the body. It is usually a result of ongoing occupational exposure to asbestos fibers which can migrate into the pleura when inhaled and set up an inflammatory response that can eventually lead to cancer. About 2,500 people in the U.S. are diagnosed with mesothelioma every year.
Disclaimer: The information in this article is for educational and informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this article. This article was written by a third party and its content reflects the views of the third party and does not necessarily reflect the views or opinions or of Surviving Mesothelioma or Cancer Monthly.
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